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Author: Michael Zand

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Medical Beat: What are T/E ratios? And why do cutoff limits vary for testosterone?

Source: mmajunkie
by Dr. Johnny Benjamin

 

Following UFC 146 headliner Alistair Overeem's failed drug test, my inbox is full of questions regarding T/E ratios and the like.

So maybe it's time for a quick physiology primer for you fight junkies.

Testosterone (T) is the naturally occurring male hormone produced primarily in the testes. Epitestosterone (E) is an inactive form of testosterone that may serve as a storage substance or precursor that gets converted to active T.

Most men have a ratio of T to E of 1:1, which means normal men have equal amounts of T and E in their blood. There is some normal ethnic and time of day variation in the normal T/E ratio (as low as 0.7:1 and as high as 1.3:1).

Statistics reveal that a ratio of up to 3.7:1 will capture 95 percent of all normal men, and a ratio of up to 5:1 will capture greater than 99 percent of all men. That's why the World Anti-Doping Agency (WADA) allows up to 4:1 (so its test is at least 95 percent accurate) and the Nevada State Athletic Commission, the NCAA and some others allow up to 6:1 (for 99 percent accuracy). The whole goal is to not label someone a cheater when he or she isn't. (Very, very rarely, some people are just freakishly high, but they have a ratio of less than 6:1).

 

 

Overeem, of course, had an eye-poppin' 14:1 ratio.

T/E ratios are used in performance-enhancing-drug (PED) monitoring because taking an external (exogenous) source of T will not effect the E levels in the blood. E stays the same, but T climbs because of the injection, and the T/E ratio follows suit and climbs.

The half-life of T is only eight hours. So every eight hours, half of the T you took is washed out of your blood. Therefore, if a cheater knows when he is likely to be tested (i.e. post-fight), he doesn't need to be a genius to know when to stop taking ("cycle off") to test lower than 6:1 or 4:1. Twenty-four hours is three half-lives, and virtually none of the extra T is left in your system to get you busted.

T abuse is making a resurgence because of therapeutic-use exemptions (TUE for TRT). Also, it naturally occurs in men's blood – unlike other anabolic steroids that at any level are unnatural (not made within the body) and must be masked in an attempt to beat the test. Cheaters don't have to mask T, so they don't worry about testing positive for a masking agent. They just need enough time for their bodies to get rid of it naturally.

If you don't know when the test is coming, you cannot adequately plan or time when to stop taking a PED like T. This, of course, is the rationale for random testing.

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NSAC Confirms That Alistair Overeem Has The Testosterone Of 14 Men

NSAC Executive Director Keith Kizer gives more information about Alistair Overeem's failed drug test

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Siyar Bahadurzada: 'When I Fight, I Fight To Kill, Every Time'

 

Source: bloodyelbow

 

It's been a long road to the UFC for Siyar Bahadurzada. After signing a four fight deal with Strikeforce that failed to produce a single fight, the young Afghan finally announced signing a UFC contract in September, 2011. He was scheduled to fight earlier this year, but had to withdraw due to a hand injury. I recently secured a quick interview with Siyar, where he discussed his upcoming April 14 bout with Paulo Thiago on UFC On Fuel TV 2, and why he left Golden Glory.

Stephie Daniels: Would you consider Paulo Thiago the biggest fight of your career thus far?

Siyar Bahadurzada: Yeah, I do. Paulo Thiago is, until now, the toughest, most skilled opponent that I've faced, because of the fact that if you're in the UFC, you're one of the best. I think the UFC has top notch fighters, but I'm also coming from some great fights at welterweight. Forget about my other fights. Just like at the ones at welterweight, especially my last three fights. They were all won by knockout. At welterweight, I feel really strong. I'm an improved fighter also. I'm looking forward to Thiago, and it will be a hell of a fight.

Stephie Daniels: Do you see this being a stand-up fight for the most part?

Siyar Bahadurzada: I hope Thiago stands with me, because that's my plan. Everybody knows I'll stand with him. I'll stand with anybody. If he stands with me, it will be fight of the night.

Stephie Daniels: Are fight of the night honors more important to you then knockout or submission of the night?

Siyar Bahadurzada: When I get in there, I always want to finish fights as soon as possible. Sometimes, things turn out differently. I never look for knockouts. Knockouts should come naturally. If you look for them, they'll never come. I just go out and fight, and while I'm fighting, sometimes I connect and finish them off. When I fight, I fight to kill, every time.

Stephie Daniels: Why did you leave Golden Glory?

Siyar Bahadurzada: I had some trust issues, and that's all I can really say about Golden Glory. I had trust issues, and that's why I decided to leave.

Stephie Daniels: Did you ever get paid for winning the United Glory tournament?

 

Siyar Bahadurzada: I just got paid three days ago.

Stephie Daniels: Were you paid in full?

Siyar Bahadurzada: Yes, I was.

Stephie Daniels: You had a very close relationship with Martin De Jong. Do you still maintain any kind of contact with him?

Siyar Bahadurzada: Well, we had problems, me and him. It came down to the point where I had to train somewhere else. I did that, and I'm training with a legendary striking coach, Lucien Carbin. I still have my friends, and I still train with them. I am prepared and well conditioned right now. I'm ready.

Stephie Daniels: You mentioned at the start of the interview that you were a little grumpy because you're cutting weight. How far out do you start your cut?

Siyar Bahadurzada: Well, I cut weight in a very strange way. I don't want to feel weak when I'm cutting weight, so I don't really follow a strict diet. I do eat specific food, and I do have a cheat day, once a week.

When I find out that I have a fight, I start watching my food, because I don't want to have to be on a strict diet, because it costs a lot of power. For the two or three months that I'm in training for a fight, I watch my food. Slowly and gradually, I get down in weight. I don't feel that I lose any power or strength that way. I do it in a very natural way that I'm used to. All these years I've done it the same way, and it works.

Stephie Daniels: What's your go to cheat food?

Siyar Bahadurzada: It's a secret. It makes me big and strong. If I tell you, then you'll be want to be in there fighting too [laughs].

Stephie Daniels: After weigh-ins, what's your last big meal?

Siyar Bahadurzada: Well, there is no such thing as a last supper, or last meal. I eat like seven times between the weigh-ins and the fight. Carbs, everything. My body is used to it. Afghan food is all carbs, and I don't eat any other food. My body accepts it and works really well with it, and that's why I'll keep doing it.

Stephie Daniels: Do you think octagon jitters will be a factor for you?

Siyar Bahadurzada: Personally, I think when I'm in the cage, and the door locks, I will be stronger. In the ring, between the ropes, he might escape, but in a cage, he will not escape, so he will be mine.

Stephie Daniels: After the Strikeforce contract failed to provide a fight, you finally got picked up by the UFC and were scheduled to fight earlier this year, but had an injury to your hand. Talk about that, and is your hand completely healed?

Siyar Bahadurzada: Well, it was bad. I felt like there was a big gift under the Christmas tree, and when you open it up, it's empty. Let me make it worse. You open it up and there's poop inside. That's how I felt about my UFC debut, because I was really excited. I waited for a long time, finally I got my chance, and a few weeks before the fight, I broke my hand.

It was really terrible, but despite my hand being in a cast, I kept training. I trained my knees, my kicks, and I jogged, so my conditioning wasn't affected in any way. The only thing that was affected was that I couldn't fight. That's the worst thing. Right now, I'm even more motivated than I was for the first fight.

My hand is 100%. I can hit hard. It's my treasure. I feel strong and confident, and I'm ready to go.

Stephie Daniels: I know you trained with Mayhem Miller for a couple months at Reign Training Center. Do you have any plans to come back to the states to train with some of the other camps out here?

Siyar Bahadurzada: Of course. After my fight, I'll come to see Jason Miller fight, and after that, I will train for some time, then come back to Europe. To be honest, the training at Reign is great over there. I mean, I might visit the Blackzilians and I would like to go to Greg Jackson's gym, to have a look and see how they train over there.

Stephie Daniels: Are there any weaknesses with Thiago that you feel you can capitalize on?

Siyar Bahadurzada: I hope there's big weakness between his ears [laughs]. To tell the truth, I respect Thiago a lot. He's a tough fighter. He's from the B.O.P.E. for God's sake. He's mentally tough, and I'm mentally tough. He's a perfect way for me to test my will and my mentality. I'll find out myself, if I'm as strong as I thought I was, or if it was just some kind of illusion. I think if I can break Thiago, I can break everybody in the UFC.

If you don't think you can beat people, or you're not mentally strong enough, then fighting doesn't make sense. When I fight, I don't fight for money. I fight for my country, and I fight for honor. Every time I fight, I put everything on the line. It's not just a sport for me. It's more than that, and I give everything.

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UFC president White furious after Overeem fails drug test

Source: the star phoenix

 

The Ultimate Fighting Championship heavyweight title match next month between champion Junior dos Santos and Alistair Overeem is in jeopardy after Overeem tested positive for elevated levels of testosterone.

A random drug test was conducted on March 27 in Las Vegas, when six fighters in the top-three bouts at UFC 146 were gathered for a press conference to promote the May 26 event. Overeem tested positive for increased testosterone levels. According to the Nevada State Athletic Commission’s Keith Kizer in a news release issued Wednesday, Overeem’s testosterone-to-epitestosterone levels were greater than 10-to-1.

Under NSAC guidelines, anything above a 6-to-1 ratio is considered a violation.

“I am beyond pissed about this,” said UFC president Dana White on Wednesday in a conference call with Canadian media that had been scheduled for one week.

“I’m so (expletive) mad right now I can’t even begin ... ”

Dos Santos, Frank Mir, Cain Velasquez, Roy Nelson and Antonio Silva all tested negative, Kizer noted.

Overeem will have to appear before the NSAC in order to be licensed in the state, Kizer said in the release.

The Dutch heavyweight made his UFC debut last December, beating former heavyweight champion Brock Lesnar in the UFC 141 main event in Las Vegas. His appearance wasn’t without controversy, however.

Overeem missed a drug test in Nevada, saying he had flown back to Holland to be with his sick mother. A pair of drug tests conducted in Europe were then mishandled until he eventually submitted a sample to an accredited lab. He passed that test, along with a subsequent test in Nevada prior to UFC 141, and was granted a conditional license. Among the conditions of that license, he would be subjected to random tests throughout 2012.

Kizer, in an email to The StarPhoenix, gave no indication that Overeem’s victory over Lesnar would be changed to a no-contest or otherwise taken away from him.

“By itself, test result has no effect on that decision,” wrote Kizer.

White was incredulous over the positive result, struggling to find words when the topic was broached.

“The worst part is that he sat in front of us and lied to us,” said White, noting that Overeem has been in UFC’s offices meeting with White and CEO Lorenzo Fertitta, where he insisted he was clean and would pass all drug tests.

The UFC president feels that health issues, the loss of money and damage to reputation should be more than enough to deter fighters from using performance-enhancing drugs.

“How (expletive) stupid do you have to be? Seriously dumb. Anybody who’s using (performance-enhancing drugs) right now is an absolute (expletive) moron,” he said.

“It’s beyond — what’s the word I’m looking for — it’s beyond belief. It’s beyond comprehension. You’re an absolute moron, a brain-dead absolute (expletive) dummy. It goes beyond a guy having any common sense whatsoever.”

Should Overeem indeed be pulled from the UFC 146 main event, it leaves a major hole in the card. Velasquez and Mir are currently scheduled to meet in a No. 1 contender’s bout, but the drug test has led to speculation that Mir would receive the title shot. Velasquez lost the belt to dos Santos last October, while Mir — himself a former champion — is on a three-fight winning streak, with victories over Mirko Cro Cop, Roy Nelson and Antonio Rodrigo Nogueira.

“I would be excited if given the opportunity to compete for the UFC’s heavyweight title at UFC 146 if the reports released earlier today regarding Alistair Overeem failing his ‘A’ sample drug test are true,” Mir said in a release issued by his management.

“I have been fortunate to be able to fight in the UFC for more than a decade, and it is a dream of mine to become the first three-time heavyweight champion in the UFC. Being able to fight Junior Dos Santos would put me one step closer to that dream.”

White said it was too early to announce any changes to the card. He said he learned of the Overeem test results literally 30 minutes before the media call.

“I don’t have a plan-B,” he said.

He also doesn’t know what Overeem’s future with the company holds. White said he’s still waiting to hear from the Nevada commission and for Fertitta to hear Overeem’s side of the story.

“It doesn’t look good, does it?” he said. “It doesn’t look good.”

 

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Nick Diaz Attorney says Use Exemption Not Needed For Out Of Competition Use

In this case, Nick Diaz tested for the presence of its metabolite, called “THC carboxylic acid,” which is an inactive ingredient of marijuana metabolite, which can stay in your system stored in your fat tissues for weeks, up to months, after use of marijuana. Most people understand that [the] psychological effects of marijuana after smoking it wear off within two to six hours. That is what the commission, the regulatory agencies, are concerned about because you don’t want somebody fighting under the influence or impaired by a psychoactive substance. Once that active ingredient wears off within two to six hours of use, then all that’s left are the residual metabolites from the metabolism of the marijuana stored in somebody’s fat tissues, which is not a controlled substance, which is not psychoactive, which is simply an inactive metabolite which has no impact on an athlete.

Yeah, but Nick Diaz wasn’t using it in-competition, so it’s completely inapplicable here. What you’re talking about are prescribed medications that an individual needs to continuously use and therefore uses during competition. Nick Diaz has a general practice of discontinuing marijuana use eight days before a fight, so he wasn’t under the influence and he wasn’t consuming an illegal substance — whether you want to call it prescription medication or medical marijuana — in-competition. So there was no need for him to seek a therapeutic use exemption. And again, that’s why Nevada and the World Anti-Doping Agency say, “We don’t care about your marijuana use before the fight. We only care about it in-competition.” And Nick doesn’t use it in-competition. It would be foolish for him to use it in-competition.

- Ross C. Goodmam, Attorney For Nick Diaz vs. sherdog.com

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Dana White vs. Vadim Finkelstein

Obviously the pressure is building up for a Fedor presence in UFC. Fedor is back with a new fighting style and people are noticing.

If Dana White dislikes the people around him he should just say so. Then Fedor can decide for himself if he want to negotiate alone or not.

MMA fans are not stupid. There is something not right about Dana's the Island story and obviously M1-Global woke up and realized UFC will never do co-promote. All things aside we all can see that UFC still is in need of a new fighters and that was something clearly visible in the UFC 146 press conference the other day. One of their biggest stars Brock Lesnar is also gone.

You can´t have a division with 15 fighters. How many times are we going to see Roy Nelson fight? It´s getting embarrassed. It's a good thing he has a steel chin and doesn't get injured a lot and can save UFC time and time again by fighting often.

Vadim is right about one thing. A potential Fedor vs X fight in the UFC could break all previous records. For us outsiders it´s just plain weird and unlogical. Who knows the real reasons?!

Maybe it's a Italian vs Russian thing? Come to think of it there is no Russian fighters in the UFC.

 

The MMA world has only one international super star and that is Fedor Emelianenko.

 

 

Here are 2 different instances Dana White had to answer about whether he will fight in UFC or not.

1.“Fedor will never fight in the UFC. He’s past his prime. You’ve heard this story before, and you know it’s true, Vadim you sneaky [email protected],” he told the Swedish outlet MMA Nytt. “We flew out to this fu-king island in the middle of nowhere and gave them the best fu-king deal in the history of mankind. And, Vadim, I bet you wish you could jump into a fu-kin’ time machine and go back and take that deal now, don’t ya? Dummy.”

 

2.UFC 146 pre-fight press conference “Not even a little bit [interested in signing Fedor].That was a guy who was made an incredible offer, and they laughed at it. He ain’t laughing now.”

 

Respons

 

Fedor’s Manager Says Dana White Is Lying About Not Wanting Emelianenko In The UFC

“You need to know Dana. If he says he has no interest in signing Fedor, then in fact, he really wants to. He says one thing, and doing another. How can you not want a fighter who can bring millions? Any fight with Fedor could break all the rating records in the UFC… We are open for dialogue. It’s just that Dana White thinks that we will come to him, kneel down and say: “We are ready for any conditions to sign a contract.” Of course, this will never happen. Fedor deserves nothing but respect. But like I said, there’s still a high demand for Fedor. We are ready to have Fedor fighting in the UFC, it’s just that we need a normal offer. And the fact that White is always saying that offered us everything “on a silver platter” is a lie.”

 

 

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Vadim Finkelstein: We are ready to have Fedor fighting in the UFC

Speaking exclusively to one of the biggest news websites in Russia, Gazeta.ru, M-1 Global boss Vadim Finkelstein spoke about the future of Fedor Emelianenko's Mixed Martial Arts career, and Dana White's recent comments about having no interest in signing "The Last Emperor". According to Finkelstein, Emelianenko's next fight will take place in Russia, most likely in St. Petersburg, with sights on fighting again this year somewhere abroad. "The demand for Fedor Emelianenko is still high," says Finkelstein, who once again declared that M-1 Global are completely open for dialogue with the UFC. Fedor Emelianenko is currently 33-4-1 in his MMA career, 2-0 since losing to Dan Henderson back in July, 2011. Here's the full translation of Vadim Finkelstein's interview with Gazeta.ru: M-1 Global Director of Operations, Evgeni Kogan, mentioned on Twitter than Fedor’s next fight may be held in Rio de Janeiro? Brazil really wants to see Fedor. There the largest media company in the country is involved there. But, again, we have plenty of offers, and not only from Rio. There’s a huge demand for Fedor as a fighter. Who else is interested in Fedor? Singapore. We are sending our representative to Singapore for negotiations. I heard about certain interest from the Indian organization Super Fight League. However, we are yet to discuss anything with them. But in general we have another very serious contact. Unfortunately, I cannot disclose this information. But the negotiations are already underway. Who will be Fedor’s next opponent? Not yet. We'll see. We have to agree on date and place of his next fight. And then, and we’ll see who’s worthy of fighting Fedor Emelianenko. But as you know, many good fighters are tied on the contract with the UFC. UFC President Dana White recently said that he has zero interest in signing Fedor... You need to know Dana. If he says he has no interest in signing Fedor, then in fact, he really wants to. He says one thing, and doing another. How can you not want a fighter who can bring millions? Any fight with Fedor could break all the rating records in the UFC. Maybe you should make the first step? We are open for dialogue. It’s just that Dana White thinks that we will come to him, kneel down and say: "We are ready for any conditions to sign a contract." Of course, this will never happen. Fedor deserves nothing but respect. But like I said, there’s still a high demand for Fedor. We are ready to have Fedor fighting in the UFC, it’s just that we need a normal offer. And the fact that White is always saying that he offered us everything “on a silver platter” is a lie.

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VIDEO: Fedor Emelianenko in a water park

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FIVE SIGNS THAT A FEDOR/UFC DEAL COULD BE CLOSE

Source: Fighters Only

Writer: JOHN JOE O'REGAN11

 

MARCH 20TH 2012

Rumours about Fedor joining the UFC crop up with considerable regularity, but always come to nothing. Negotiations have been underway several times with both sides blaming the other when they fail.

UFC president Dana White calls Fedor’s management ‘crazy’ for their insistence on co-promoting any events featuring Fedor, while Fedor’s management have proffered various reasons over the years as to why a UFC contract was never acceptable to them.

A Mexican (or at least, Russian) standoff has persisted ever since the demise of Pride FC but recently it seems both sides have thawed a little. Fedor’s management in particular seem to have moderated their tone and their demands.

Five signs that Fedor and the UFC could be about to make a deal happen:

1. Fedor’s name used to be mud in Zuffa circles but of late he has been getting a lot of mention on broadcasts. This is very often a precursor to someone’s arrival in the UFC. The only caveat is that the mentions have largely related to his losses - this could be an attempt to devalue his bargaining position with the UFC, or make him seem a less attractive asset if he does fight elsewhere.

According to the message-board chatter, some fans think that it might be because the UFC simply thinks Fedor is no longer a threat or an asset to rival promotions and so they feel free to mention him. It is plausible, but I don’t think its the most likely explanation.

2. All co-promotion demands have now been dropped. This was the major stalling point for the UFC side of negotiations. There was no way they were ever going to agree to co-promote with anyone, let alone a company that runs a rival promotion. That was at the peak of Fedor’s career - once he lost three in a row, the very notion became a joke and M-1 has finally seen the light and dropped it.

The UFC had agreed to allow Fedor to sport M-1 logos on his shorts, apparel and cage-side banner if he signed for them. That alone was a massive concession which was without precedent. If M-1 do manage to sign Fedor to the UFC, they are likely to rue the day they turned the original offers down as the UFC is unlikely to offer them anywhere near such liberties again. There likely won't even be a plate of biscuits on the table during the next meeting.

3. M-1 executives say that a UFC deal is the direction that they are hoping to move in. Most recently one of their European office responded to a fan enquiry on this subject with “Wait and see.” Truth be told, they are not only wide open to a UFC deal, they badly want one. There is very little real money to be made in MMA these days unless under the UFC banner.

Singapore’s One FC or the Indian show SFL could conceivably come up with a one-off decent payday but for the kind of money Fedor is used to, on a consistent basis, the UFC is the only place to be. And despite his slide in form and status, he would probably still benefit from his Pride FC days, if the UFC’s treatment of Mirko CroCop or Rampage Jackson is anything to go by. UFC co-owner Lorenzo Fertitta was a huge fan of Pride and takes a personal interest in the big-name veterans of the promotion, giving them a leeway that few others get.

4. The UFC is first and foremost a pay-per-view company, selling sports-entertainment. As such, storylines are a big part of matchmaking and a good storyline greatly benefits PPV sales. Shows such as Primetime are used to tell, or create, a story between fighters and thus generate interest in the bout among potential customers. Fedor slots very neatly into this model.

He has the Pride FC history, the aura of mystique, the exoticism of being from a tiny backwater in the traditional enemy Russia, an impressive video-reel and a history with some fighters currently on the UFC heavyweight roster. Most recently he has been talking about his desire to rematch Fabricio Werdum, who in 2008 became the first fighter to legitimately defeat him and who presaged his slide into an 0-3 run.

Werdum had an excellent performance against Roy Nelson recently, demonstrating massively improved striking skills and a crowd-pleasing style which had not previously been his hallmark. If he can carry that forward, he will slot into the contender picture well.

If Fedor wants the rematch and the UFC thinks Werdum is the likely winner, it must surely be attractive to them. They get to build Werdum into a legitimate contender via a very sellable rematch. And as they own the Pride FC and Strikeforce video libraries, they can document most of the careers of both fighters and make for a very compelling pre-fight build-up.

5. The UFC returned to Japan recently and staged a successful event with a card that featured a mix of new talent and former Pride FC figures. Chief among those was Quinton ‘Rampage’ Jackson, but as he is apparently taking free of his contract after his next UFC match the company might want to replace him with a legend of similar stature for the Japanese/Far East market. Enter Fedor.

There is also a dearth of Russian talent on the UFC roster at present and while that isn’t a huge hole in their game - Russia is hardly awash with PPV buyers - it is a gap that it would not hurt to fill. Aside from Russia, Fedor enjoys popularity in South Korea and various eastern European and former soviet states. Multiple media-attention birds could be killed with one stone by signing a Slav of such stature.

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Fedor Emelianenko Sumo Wrestle

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